Advances and Challenges in CRISPR/Cas-Based Fungal Genome Engineering for Secondary Metabolite Production: A Review
Fungi represent an important source of bioactive secondary Sweater metabolites (SMs), which have wide applications in many fields, including medicine, agriculture, human health, and many other industries.The genes involved in SM biosynthesis are usually clustered adjacent to each other into a region known as a biosynthetic gene cluster (BGC).The re